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. 2017 Mar 1;10(3):323–336. doi: 10.1242/dmm.026682

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© 2017. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 7. — Behavior-induced modulation of plasticity in the DG is altered in cocaine-withdrawn mice. Change (Δ) in DG marker expression induced by behavior in VEH-Behav and COC-Behav mice compared with their respective control group (represented by zero in the graphs). The VEH-Behav mice showed notable behavior-induced changes, reducing basal c-Fos expression (A) but increasing GABAergic neuron populations (B-D) and adult hippocampal neurogenesis (E,F) in the DG after behavior training. However, the behavior-induced upregulation of PV and NPY was blunted in the supragranular layer of the COC-Behav mice (B,C). (G) In addition, the COC-Behav mice showed a blunted regulation of PCNA (E) and a reduced maturation of the young DCX⁺ neurons in the infragranular blade. Results are represented as mean±s.e.m. difference from the respective control group. Post hoc LSD test: *P<0.05 for VEH versus COC. One-sample Student's t-tests to compare means versus zero: ^$P<0.05, ^$$P<0.001 (this comparison indicates a significant change from the respective control group).