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. 2017 Mar 1;10(3):235–243. doi: 10.1242/dmm.027474

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© 2017. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 4. — VSG reduces hypothalamic ER stress, hypothalamic inflammatory signaling and circulating NE concentrations. Representative immunoblots of pPERK^Thr980, PERK, peIF2α^Ser51, eIF2α, pIRE1α^Ser724, IRE1α, ATF6, TNFα and tubulin (bottom) (n=3 per group). Results are quantified in densitometric units and pPERK^Thr980 is expressed relative to PERK, peIF2α^Ser51 relative to eIF2α, pIRE1α^Ser724 relative to IRE1α and ATF6 and TNFα relative to tubulin (top) in hypothalamus (A) and brainstem (B) samples collected 2.5 months after surgery (n=6 per group). (C) Fasting plasma NE at 2.5 months after surgery. VSG, VSG-operated mice; S-AL, sham-operated ad libitum-fed mice; S-WM, sham-operated weight-matched mice. *P<0.05, compared with S-AL; ⁺P<0.05, compared with S-WM by Student's t-test. Data are expressed as mean±s.e.m.