The expression of KLF2, KLF4 and KLF5 during mammalian pre-implantation embryo development. Diagram of mouse pre-implantation embryo development, highlighting the stages at which KLF2, KLF4 and KLF5 genes are expressed; the expression of these factors in human pre-implantation embryos is also indicated. Patterns of expression are based on findings reported by Blakeley et al. (2015) and Lin et al. (2010). EPI, epiblast; ICM, inner cell mass; PE, primitive ectoderm; TE, trophectoderm.