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. 2017 Feb 6;6(3):348–357. doi: 10.1242/bio.021212

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© 2017. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 3. — Pdgfra homozygous mutants exhibit abnormal cardiac phenotypes. An incross of the pdgfra gene-trapped strain carrying a Tg(cmlc2:EGFP) transgene was used to investigate the cardiac phenotype. (A) At 48 hpf, mild and severe −/− mutants present with abnormal cardiac looping; severe −/− embryos also develop an enlarged atrium and pericardial edema. (B) At 96 hpf, the hearts of mild −/− mutants remain incompletely looped, while severe −/− mutants present with collapsed chambers and pericardial edema. Arrows pointing at ventricle (V) and atrium (A). The fish cranium is on the left. Scale bar: 100 μm.