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. 2016 Dec 29;10(1):4. doi: 10.3390/ph10010004

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© 2016 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(A) R8 birth; Ato (pink/red), Sens (blue) and secondary R cells (grey); (B) CK2 and Mitogen Activated Protein Kinase (MAPK) activate M8 at stage-2/3 of the MF, and after R8 selection, PP2A and CK1 + Slimb mediate inactivation and/or destruction; (C) Eye phenotypes of CK2 and M8 mutants; (D) Functional domains in M8, and location of the phosphorylation domain (PD) in the C-terminal domain (CtD). The WRPW motif in M8 binds the essential co-repressor Groucho, and M8* (the product of the E(spl)D mutation) eliminates the CtD; (E) Regulation of cis-inhibited M8 by CK2 and MAPK. Note that in cis-inhibited M8, the PD blocks either HLH (blue) or Orange domains preventing interaction with Atonal; (F) Conservation of the PD in Drosophila M8/M5/M7/Mγ and human/mouse Hes6; (G) Model for CK2 regulation of Drosophila M8 and mammalian Hes6. Dotted line denotes non-canonical mode of Hes6 action.