Table 1.
CK2 targets from FlyBase (November 2016).
| Protein | Function | Effect of Phosphorylation |
|---|---|---|
| Ankyrin-2 | Cytoskeletal Adaptor | Maintenance of synaptic stability |
| Antennapedia | Transcription Factor | Spatial restriction of activity |
| Armadillo | Transcription Factor | Phosphorylation triggers degradation |
| Cactus | Transcription Factor | Required for activity during axis formation |
| Clock | Transcription Factor | Stabilizes Clock |
| CREB2 | Transcription Factor | Inhibits DNA binding |
| Dishevelled (dsh) | Transcription Factor | Influences Wg/Wnt signaling |
| dMi-2 (DPIM) | Chromatin Structure | Inhibits nucleosome-stimulated ATPase |
| E(spl)-M8/M5/M7 | Transcription Factor | Phosphorylation required for repressor activity |
| Engrailed | Transcription Factor | Phosphorylation enhances DNA-binding |
| Enhancer of Rudimentary | Transcription Factor | Promotes and inhibits activity |
| FMR1 (DPIM) | RNA-Binding | Affects dimerization and RNA-binding |
| GAGA factor (519) | Transcription Factor | Reduced DNA binding affinity |
| Groucho | Transcription Factor | Stimulates short range repression |
| Hairy | Transcription Factor | Promotes repressor activity |
| Heterochromatin protein HP1 | Chromatin Structure | Stimulates DNA binding |
| mushroom body miniature | Ribosome Biogenesis | Promotes nucleolar localization |
| NAP1 | Chromatin Structure | Affects degradation and cellular locale |
| Odd | Transcription Factor | Inhibits Groucho binding and repression |
| Orb (CPEB-family) | RNA-Binding | Promotes Orb activity |
| P element Somatic Inhibitor (PSI) | Splicing factor | Modulates interactions with splicing factors |
| Period | Circadian Clock | Promotes nuclear entry |
| Raf | Protein Kinase | Required for ERK activation |
| Ribosomal S6 kinase | Protein Kinase | Required for activity |
| RPL-22 | Ribosome Structure | Unknown |
| Smoothened | Signaling | Stabilizes and promotes Hedgehog signaling |
| Syntaxin-1 | Membrane Protein | Stimulates interaction with Dopamine Transporter |
| Timeless | Circadian Clock | Promotes nuclear entry |
| Topoisomerase II (DPIM) | DNA-replication | Stimulates activity |
| Warts | Protein Kinase | Indirectly promotes Warts suppression of Yorkie |
DPiM (in red) denotes proteins identified in the Drosophila Protein Interaction Map.