Table 2.
Subunit diversity and non-redundancy of Dm-CK2β isoforms.
| Genes Encoding CK2 Subunits in Drosophila | |||
| Gene (Chromosome) | Isoforms | Alleles | Nature |
| CK2α (III) | Single | CK2α-Tik | M161K + E165D |
| CK2α-TikR | Loss of Function | ||
| CK2α-MB00477 | Hypomorphic | ||
| CK2α-G703 | W279G | ||
| CK2α-H3091 | D212N | ||
| CK2β (X) | Multiple | CK2βAndante | M166I |
| CK2βmbuP1 | Hypomorphic | ||
| CK2βmbuΔA26-2L | Loss of Function | ||
| Stellate (X) | Single | None | N/A |
| CK2β′ (II) | Single | None | N/A |
| SSL/CK2-βTes (II) | Single | None | N/A |
| Phenotypes of Ectopic Expression | |||
| Isoform | Tissue | Overexpression Phenotype | |
| CK2α-WT | Proneural cluster | No Effect | |
| CK2α-Tik | Proneural cluster | Impaired Notch Signaling (eye & bristle) | |
| CK2α-M161K | Proneural cluster | Impaired Notch Signaling (eye & bristle) | |
| CK2α-E165D | Proneural cluster | Impaired Notch Signaling (eye & bristle) | |
| CK2β-VII-a | Ubiquitous | No Effect | Rescues CK2β∆A26 |
| CK2β-VII-b | Ubiquitous | Dominant Lethal | Rescues CK2β∆A26 |
| CK2β-VII-c | Ubiquitous | No Effect | Rescues CK2β∆A26 |
| CK2β-VII-d | Ubiquitous | Dominant Lethal | No rescue of CK2β∆A26 |
| CK2β-VII-d-VI | Ubiquitous | No Effect | No rescue of CK2β∆A26 |
| Stellate | Not Tested | N/A | Not tested |
| CK2β′ | Ubiquitous | Dominant Lethal | No rescue of CK2β∆A26 |
| SSL/CK2-βTes | Ubiquitous | Dominant Lethal | No rescue of CK2β∆A26 |
Yellow box highlights ability to complement the lethality of CK2β∆A26 mutants. CK2-β isoforms that fail to rescue loss of the X-linked CK2-β gene are indicated in red.