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. 2017 Feb 12;10(1):24. doi: 10.3390/ph10010024

Figure 3.

Figure 3

Tumour volumes and survival rates for 6-day metronomic treatment. (A) Survival Kaplan-Meier curve for metronomic CX-4945 treated mice (n = 6), blue line, metronomic TMZ treated mice (n = 6), red line, CX-4945 and TMZ metronomic treated mice (n = 6), green line, and control mice (n = 6), black line. Significant differences (p < 0.05) were observed between all treatment groups analysed in comparison with control mice; (B) Tumour volumes of control mice (n = 6); (C) Tumour volumes of metronomic CX-treated mice (n = 6); (D) Tumour volumes of metronomic TMZ-treated mice (n = 6); (E) Tumour volumes of metronomic CX and TMZ- treated mice (n = 6). Significant differences were found between groups (p < 0.05) when comparing control mice with treated mice, and when comparing different treatments between them (TMZ, CX-4945 and combined TMZ and CX-4945). The dashed lines indicate therapy administration points. Cxxxx corresponds to a unique alpha-numeric animal identifier code in the GABRMN group.