Table 2.
Biodistribution data of [68Ga]Ga-TRAP(NT4)3 expressed as percent injected dose per gram tissue (%ID/g) ± standard deviation of 2–3 HT29 tumor-bearing nude mice for each time point.
| Organ | 60 min | 90 min | 60 min Blocking 1 | 60 min Blocking 2 |
|---|---|---|---|---|
| blood | 0.13 ± 0.02 | 0.04 ± 0.02 | 0.07 ± 0.01 | 0.40 ± 0.01 |
| lung | 2.76 ± 0.53 | 2.37 ± 0.21 | 1.61 ± 0.42 | 6.06 ± 1.19 |
| liver | 11.18 ± 0.30 | 11.71 ± 0.48 | 8.30 ± 0.87 | 11.21 ± 2.27 |
| kidney | 94.55 ± 10.84 | 102.37 ± 29.88 | 96.26 ± 8.83 | 99.91 ± 15.52 |
| heart | 0.13 ± 0.02 | 0.35 ± 0.37 | 0.15 ± 0.11 | 0.45 ± 0.13 |
| spleen | 3.72 ± 0.09 | 3.45 ± 0.38 | 2.20 ± 0.39 | 3.75 ± 0.81 |
| brain | 0.04 ± 0.01 | 0.02 ± 0.01 | 0.06 ± 0.07 | 0.07 ± 0.02 |
| muscle | 0.09 ± 0.03 | 0.11 ± 0.08 | 0.10 ± 0.05 | 0.16 ± 0.03 |
| femur | 1.51 ± 0.12 | 1.17 ± 0.21 | 0.74 ± 0.14 | 1.72 ± 0.12 |
| HT29 tumor | 1.74 ± 0.21 | 1.44 ± 0.13 | 1.10 ± 0.20 | 0.60 ± 0.13 |
| intestine | 1.50 ± 0.42 | 1.31 ± 0.20 | 0.49 ± 0.08 | 0.49 ± 0.07 |
1 Co-injection of [68Ga]Ga-TRAP(NT4)3 and TRAP(NT4)3 (20 nmol per mouse); 2 Co-injection of [68Ga]Ga-TRAP(NT4)3 and NT4 (100 nmol per mouse).