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. 2016 Dec 30;49(3):151–159. doi: 10.1152/physiolgenomics.00120.2016

Table 2.

The 20 top ranked DUBs base on probability of interacting with plasma membrane transporters

Rank 2 Gene Symbol 3 Initial Probability 4 mpkCCD Transcriptome 5 mpkCCD Proteome 6 UniProt Subcellular Location 7 Dot Product 8 Rat CCD Transcriptome 9 Final Posterior Prob.
1 OTUB1 0.0091 0.0195 0.0340 0.0428 0.0944 0.1203 0.1203
2 USP14 0.0091 0.0191 0.0332 0.0428 0.0921 0.1173 0.1173
3 PSMD7 0.0091 0.0188 0.0327 0.0428 0.0907 0.1155 0.1155
4 PSMD14 0.0091 0.0196 0.0342 0.0427 0.0795 0.1012 0.1012
4 USP7 0.0091 0.0196 0.0342 0.0427 0.0786 0.1001 0.1001
6 USP9X 0.0091 0.0172 0.0300 0.0427 0.0783 0.0996 0.0996
7 OTUD4 0.0091 0.0196 0.0342 0.0427 0.0805 0.0876 0.0876
8 USP10 0.0091 0.0196 0.0341 0.0427 0.0947 0.0709 0.0709
8 UCHL5 0.0091 0.0196 0.0342 0.0426 0.0294 0.0375 0.0375
8 PRPF8 0.0091 0.0196 0.0342 0.0416 0.0100 0.0127 0.0127
11 EIF3F 0.0091 0.0020 0.0034 0.0416 0.0095 0.0121 0.0121
12 USP47 0.0091 0.0196 0.0341 0.0409 0.0095 0.0120 0.0120
13 USP8 0.0091 0.0191 0.0333 0.0397 0.0092 0.0118 0.0118
14 USP15 0.0091 0.0182 0.0317 0.0394 0.0088 0.0105 0.0105
14 BRCC3 0.0091 0.0139 0.0243 0.0375 0.0067 0.0086 0.0086
16 USP4 0.0091 0.0137 0.0239 0.0373 0.0066 0.0084 0.0084
17 OTUD6B 0.0091 0.0132 0.0231 0.0318 0.0064 0.0082 0.0082
18 VCPIP1 0.0091 0.0146 0.0254 0.0304 0.0071 0.0081 0.0081
18 UCHL3 0.0091 0.0196 0.0341 0.0299 0.0585 0.0074 0.0074
18 USP5 0.0091 0.0171 0.0298 0.0299 0.0585 0.0074 0.0074

The 20 DUBs most likely to interact with plasma membrane proteins based on Bayesian analysis. The Bayesian analysis is sequential. Columns 4–8 show the Bayesian posterior probabilities for DUB interaction with plasma membrane proteins in the cortical collecting duct using the data sets described in Table 1.