Table 2.

The 20 top ranked DUBs base on probability of interacting with plasma membrane transporters

Rank	2 Gene Symbol	3 Initial Probability	4 mpkCCD Transcriptome	5 mpkCCD Proteome	6 UniProt Subcellular Location	7 Dot Product	8 Rat CCD Transcriptome	9 Final Posterior Prob.
1	OTUB1	0.0091	0.0195	0.0340	0.0428	0.0944	0.1203	0.1203
2	USP14	0.0091	0.0191	0.0332	0.0428	0.0921	0.1173	0.1173
3	PSMD7	0.0091	0.0188	0.0327	0.0428	0.0907	0.1155	0.1155
4	PSMD14	0.0091	0.0196	0.0342	0.0427	0.0795	0.1012	0.1012
4	USP7	0.0091	0.0196	0.0342	0.0427	0.0786	0.1001	0.1001
6	USP9X	0.0091	0.0172	0.0300	0.0427	0.0783	0.0996	0.0996
7	OTUD4	0.0091	0.0196	0.0342	0.0427	0.0805	0.0876	0.0876
8	USP10	0.0091	0.0196	0.0341	0.0427	0.0947	0.0709	0.0709
8	UCHL5	0.0091	0.0196	0.0342	0.0426	0.0294	0.0375	0.0375
8	PRPF8	0.0091	0.0196	0.0342	0.0416	0.0100	0.0127	0.0127
11	EIF3F	0.0091	0.0020	0.0034	0.0416	0.0095	0.0121	0.0121
12	USP47	0.0091	0.0196	0.0341	0.0409	0.0095	0.0120	0.0120
13	USP8	0.0091	0.0191	0.0333	0.0397	0.0092	0.0118	0.0118
14	USP15	0.0091	0.0182	0.0317	0.0394	0.0088	0.0105	0.0105
14	BRCC3	0.0091	0.0139	0.0243	0.0375	0.0067	0.0086	0.0086
16	USP4	0.0091	0.0137	0.0239	0.0373	0.0066	0.0084	0.0084
17	OTUD6B	0.0091	0.0132	0.0231	0.0318	0.0064	0.0082	0.0082
18	VCPIP1	0.0091	0.0146	0.0254	0.0304	0.0071	0.0081	0.0081
18	UCHL3	0.0091	0.0196	0.0341	0.0299	0.0585	0.0074	0.0074
18	USP5	0.0091	0.0171	0.0298	0.0299	0.0585	0.0074	0.0074

The 20 DUBs most likely to interact with plasma membrane proteins based on Bayesian analysis. The Bayesian analysis is sequential. Columns 4–8 show the Bayesian posterior probabilities for DUB interaction with plasma membrane proteins in the cortical collecting duct using the data sets described in Table 1.