Table 4.

Altered signaling pathways associated with VSMC differentiation

Wnt	Fold Change	TGFB	Fold Change
Wnt2	1.67	Bmp2k	1.92
Wnt2b	−1.57	Bmper	1.70
Wnt5a	−2.43	Bmp1	1.49
Wif1	−2.83	Bmpr2	−1.44
Fzd5	−1.33	Crim1	−1.72
Fzd7	−1.95	Bmpr1a	−1.84
Fzd8	−2.62	Bmp4	−2.35
Pygo1	−1.95	Bmp6	−2.53
Hedgehog	Fold Change	Bmpr1b	−2.72
Hhipl1	1.91	Bmp3	−3.15
Hhat	1.32	Tab1	1.07
Hhip	−6.62	Tgfbr1	−1.78
Gli2	−1.85	Tgfb1i1	−1.79
Gli1	−1.89	Tgfb2	−1.85
		Tgfb3	−2.55
Notch	Fold Change	Acvr1	−1.16
Notch3	−1.92	Acvrl1	−1.25
Jag 1	−1.50	SMAD4	−1.20
Hey 2	−2.76	SMAD6	−2.40
		SMAD9	−2.60

Examples of changes mRNAs encoding signaling molecules that are known to play a role in regulating the differentiation of VSMCs are indicated. Data are excerpted from Supplemental Table S2.