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. 2017 Mar 31;7:45867. doi: 10.1038/srep45867

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Copyright © 2017, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Upper and lower panels show schematic gastric gland in pups (18 days) and young- adult rats (30 days), respectively, according to the distribution of cells in suckling and early- weaned rats treated or not with RU486. Effects are noted as increase (⇑), decrease (⇓) and unresponsive (-) for the different markers used to identify genes (italics), proteins and populations of surface mucous (SM), mucous neck (MNC) and zymogenic cells (ZC). Genes, proteins and glycoproteins were studied separately, as indicated, and we demonstrated that corticosterone activity induced the expression of molecular markers involved in the differentiation of secretory cells in pups and part of effects were maintained in young- adults, suggesting a change of program in these cells.