Table 3. Summarized results of association analyses between seven SNPs and four clinical assessments of RA with combined RA patients sample from both discovery and validation stages.
SNP | BP | A1 | BETA_DAS28 | STAT_DAS28 | P_DAS28 | BETA_VAS | STAT_VAS | P_VAS | OR_EA | STAT_EA | P_EA | OR_ERO | STAT_ERO | P_ERO |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
rs911263 | 68286876 | C | 0.0048 | 0.11 | 0.9126 | −0.07 | −0.28 | 0.7766 | 0.92 | −0.31 | 0.7569 | 0.52 | −4.18 | 2.89 × 10−5 |
rs911256 | 68306863 | C | −0.0061 | −0.12 | 0.9054 | −0.14 | −0.49 | 0.6213 | 1.10 | 0.36 | 0.7170 | 0.71 | −1.89 | 0.0594 |
rs17105837 | 68562024 | A | 0.0374 | 1.39 | 0.1647 | 0.25 | 1.63 | 0.1046 | 0.77 | −1.70 | 0.0887 | 1.05 | 0.47 | 0.6378 |
rs2525504 | 68562256 | G | 0.0127 | 0.47 | 0.6420 | 0.10 | 0.67 | 0.5053 | 0.67 | −2.48 | 0.0132 | 1.00 | 0.00 | 0.9963 |
rs4531674 | 68600026 | A | 0.0258 | 0.63 | 0.5292 | 0.13 | 0.55 | 0.5850 | 0.95 | −0.21 | 0.8345 | 0.89 | −0.78 | 0.4339 |
rs17756404 | 68601208 | A | 0.0188 | 0.72 | 0.4703 | 0.13 | 0.84 | 0.3985 | 0.81 | −1.45 | 0.1484 | 1.03 | 0.32 | 0.7509 |
rs12878761 | 68601648 | A | 0.0406 | 0.95 | 0.3414 | 0.27 | 1.09 | 0.2755 | 0.96 | −0.15 | 0.8784 | 1.01 | 0.03 | 0.9732 |
The four clinical assessments, VAS, DAS28, extra-articular and erosion were indicated as VAS, DAS28, EA and ERO, respectively. The significant results were indicated in bold.