Figure 6. Model depicts the effects of Y14 depletion on the expression of cell cycle and apoptotic factors.

Y14 depletion induces the expression of p53β and aberrant isoforms of many other cell cycle and apoptotic regulators via splicing regulation (solid lines). CPT can counteract the effect of Y14 depletion on aberrant splicing. Y14 depletion also increases total p53 protein level possibly by preventing p53 ubiquitination (dashed line), and thus influences p53 signaling. Moreover, Y14 deficiency leads to inefficient p21 protein synthesis (dotted line), leading to reduction of the level of steady p21 protein. The mechanisms of Y14-reguated protein stability control and selective translational control remain further investigation (grey question marks).