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. 2017 Mar 31;7:45515. doi: 10.1038/srep45515

Figure 3. Model of interaction between mammalian GC-E, GCAP1 and GCAP2.

Figure 3

Domains of GC-E are assigned as extracellular domain (ECD, corresponding to the intradiskal part in rod disk membranes), transmembrane domain (TM), juxta-membrane domain (JMD), kinase homology domain (KHD), dimerization domain (DD) and catalytic domain (CD). Two contradicting concepts of GCAP binding to GC-E are shown. References and details are provided in the main text. For reasons of simplicity, we sketched the GC/GCAP complex showing only one GC dimer. Each GCAP form might also bind separately to a GC dimer.