Table 2.
Top 5 enriched GO terms and KEGG pathways for the miRNA sponges in each module and module-specific interactions
| miRSM | Items | #miRNA sponges | Adjusted p-value |
|---|---|---|---|
| Module 1 | GO:0000278-Mitotic cell cycle | 45 | 7.36E-28 |
| GO:0051301-Cell division | 43 | 4.10E-27 | |
| GO:0007049-Cell cycle | 41 | 4.61E-18 | |
| GO:0007067-Mitosis | 28 | 2.50E-17 | |
| GO:0000236-Mitotic prometaphas | 20 | 3.59E-16 | |
| KEGG:04110-Cell cycle | 17 | 7.73E-10 | |
| KEGG:04914-Progesterone-mediated oocyte maturation | 9 | 0.000432 | |
| KEGG:05110-Vibrio cholerae infection | 7 | 0.000676 | |
| KEGG:03060-Protein export | 5 | 0.000728 | |
| KEGG:04114-Oocyte meiosis | 9 | 0.001271 | |
| Module 2 | GO:0007165-Signal transduction | 124 | 2.37E-26 |
| GO:0007275-Multicellular organismal development | 106 | 1.41E-24 | |
| GO:0045944-Positive regulation of transcription from RNA polymerase II promoter | 73 | 2.16E-19 | |
| GO:0000122-Negative regulation of transcription from RNA polymerase II promoter | 55 | 3.39E-15 | |
| GO:0007155-Cell adhesion | 62 | 9.26E-14 | |
| KEGG:04060-Cytokine-cytokine receptor interaction | 35 | 5.45E-10 | |
| KEGG:04080-Neuroactive ligand-receptor interaction | 33 | 1.40E-08 | |
| KEGG:05200-Pathways in cancer | 36 | 2.53E-08 | |
| KEGG:04510-Focal adhesion | 26 | 1.40E-07 | |
| KEGG:04144-Endocytosis | 25 | 3.30E-07 | |
| Module 3 | GO:0007165-Signal transduction | 113 | 1.01E-22 |
| GO:0045944-Positive regulation of transcription from RNA polymerase II promoter | 73 | 6.85E-21 | |
| GO:0007275-Multicellular organismal development | 94 | 5.77E-20 | |
| GO:0000122-Negative regulation of transcription from RNA polymerase II promoter | 52 | 1.98E-14 | |
| GO:0007155-Cell adhesion | 58 | 9.76E-13 | |
| KEGG:04060-Cytokine-cytokine receptor interaction | 31 | 4.46E-08 | |
| KEGG:04080-Neuroactive ligand-receptor interaction | 31 | 5.24E-08 | |
| KEGG:05200-Pathways in cancer | 34 | 6.92E-08 | |
| KEGG:04920-Adipocytokine signaling pathway | 15 | 9.78E-08 | |
| KEGG:04010-MAPK signaling pathway | 29 | 2.07E-07 | |
| Module 4 | GO:0000278-Mitotic cell cycle | 42 | 2.03E-32 |
| GO:0051301-Cell division | 40 | 2.79E-31 | |
| GO:0000236-Mitotic prometaphase | 20 | 6.71E-20 | |
| GO:0007067-Mitosis | 26 | 7.54E-20 | |
| GO:0006260-DNA replication | 24 | 8.54E-20 | |
| KEGG:04110-Cell cycle | 14 | 2.48E-09 | |
| KEGG:03060-Protein export | 5 | 0.00015 | |
| KEGG:05110-Vibrio cholerae infection | 6 | 0.000517 | |
| KEGG:04914-Progesterone-mediated oocyte maturation | 6 | 0.003029 | |
| KEGG:04141-Protein processing in endoplasmic reticulum | 8 | 0.003089 | |
| Module-specific | GO:0007275-Multicellular organismal development | 146 | 6.67E-30 |
| GO:0007165-Signal transduction | 165 | 2.46E-29 | |
| GO:0045944-Positive regulation of transcription from RNA polymerase II promoter | 95 | 5.49E-21 | |
| GO:0000122-Negative regulation of transcription from RNA polymerase II promoter | 72 | 7.02E-17 | |
| GO:0007264-Small GTPase mediated signal transduction | 58 | 6.02E-15 | |
| KEGG:05200-Pathways in cancer | 56 | 2.26E-13 | |
| KEGG:04510-Focal adhesion | 39 | 2.92E-11 | |
| KEGG:04144-Endocytosis | 34 | 1.77E-08 | |
| KEGG:04060-Cytokine-cytokine receptor interaction | 39 | 7.93E-08 | |
| KEGG:04810-Regulation of actin cytoskeleton | 34 | 9.26E-08 |
The p-values are adjusted by Benjamini-Hochberg (BH) method