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. 2017 Mar 31;17:233. doi: 10.1186/s12885-017-3221-9

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Kaplan-Meier plot of palpable mammary tumors in congenic rats. Onset of tumors in rats exposed to a MNU at 3 weeks of age, b MNU at 8 weeks of age, and c DMBA at 8 weeks of age. Squares illustrate rapid and circles illustrate slow acetylator Nat2 congenic rats. Rapid acetylator congenic rats had a significantly (p<0.05) shorter latency for development of first palpable mammary tumor compared to slow acetylator congenic rats after MNU administration at either 3 or 8 weeks of age. Similar findings were obtained after DMBA administration at 8 weeks of age although the difference was not significant (p=0.065)