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. 2017 Mar 31;17:184. doi: 10.1186/s12906-017-1695-2

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — The regeneration of dissected sciatic nerves in the chambers filled with AOF. Sprague-Dawley rats weighing 220 ± 20 g underwent silicone chamber placement. The chambers in the right legs were filled with various concentrations of AOF as indicated. The sciatic nerves from the chamber in rats with surgery were taken. As shown by western blot analyses, AOF treatment upregulated PCNA, cyclin A, cyclin E (a) and the IGF-1, p-Akt, Bcl-XL (b) in a dose-dependent manner. α-tubulin was used as a loading control