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. 2017 Mar 31;17:184. doi: 10.1186/s12906-017-1695-2

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Schematic model of the survival and proliferative effects of AOF extract on RSC96 Schwann cell. Stimulation of Schwann cell with AOF extract activate IGF-I signaling, leading to upregulation of the PI3K/Akt pathway and activation of the cell cycle regulatory proteins cyclin D1, E and A, resulting in the survival and proliferation of RSC96 Schwann cell