Table 2.
Characteristics and correlation with sarcopenia in 89 patients undergoing radical cystectomy
| Variables | Total cases, n (%) | Non-sarcopenia, n (%)† | Sarcopenia, n (%) † | P value ¶ |
|---|---|---|---|---|
| Total cases | 89 (100%) | 67 (75%) | 22 (25%) | - |
| Age at RC (year-old), median (IQR) | 71 (48–83) | 72 (66–75) | 71 (62–76) | 0.22 |
| BMI (Kg/m2), median (IQR) | 22.7 (20.9–24.7) | 23.3 (21.6–24.75) | 21.8 (19.3–23.0) | 0.013 |
| Sex | 0.16 | |||
| Male | 70 (79%) | 55 (82%) | 15 (68%) | |
| Female | 19 (21%) | 12 (18%) | 7 (32%) | |
| ECOG-PS | 1.0 | |||
| 0 | 82 (92%) | 62 (93%) | 20 (91%) | |
| ≥ 1 | 7 (8%) | 5 (7%) | 2 (9%) | |
| Clinical T category | 0.007 | |||
| NMIBC | 6 (7%) | 2 (3%) | 4 (18%) | |
| T2 | 42 (47%) | 36 (54%) | 6 (27%) | |
| T3 | 19 (21%) | 16 (24%) | 3 (14%) | |
| T4 | 22 (25%) | 13 (19%) | 9 (41%) | |
| Clinical N category | 0.83 | |||
| 0 | 78 (88%) | 59 (88%) | 19 (86%) | |
| ≥ 1 | 11 (12%) | 8 (12%) | 3 (14%) | |
| Variant histology | 0.21 | |||
| No | 68 (76%) | 49 (73%) | 19 (86%) | |
| Yes | 21 (24%) | 18 (27%) | 3 (14%) | |
| Preoeprative nutrition index, median (IQR) | ||||
| PNI | 47.0 (43.5–50.2) | 47.5 (44.0–51.0) | 45.2 (38.8–48.6) | 0.08 |
| CONUT score | 2 (1–3) | 2 (1–3) | 2 (1–3) | 0.30 |
| Preoeprative blood level, median (IQR) | ||||
| Hb (g/dL) | 11.2 (10.2–12.7) | 11.6 (10.4–12.7) | 10.8 (9.8–12.1) | 0.07 |
| CRP (mg/dL) | 0.2 (0.1–0.7) | 0.2 (0.1–0.6) | 0.4 (0.1–1.7) | 0.20 |
| Albumin (g/dL) | 4.0 (3.7–4.2) | 4.0 (3.8–4.2) | 3.9 (3.6–4.2) | 0.47 |
| Sodium (mEq/L) | 141 (139–143) | 141 (139–143) | 140 (138–143) | 0.09 |
| LDH (U/L) | 180 (159–201) | 180 (159–201) | 181 (139–205) | 0.54 |
| Neoadjuvant chemotherapy | 0.23 | |||
| No | 52 (58%) | 38 (57%) | 14 (64%) | |
| Yes | 37 (42%) | 29 (43%) | 8 (36%) | |
| Adjuvant chemotherapy | 0.42 | |||
| No | 75 (84%) | 56 (84%) | 19 (86%) | |
| Yes | 14 (16%) | 11 (16%) | 3 (14%) | |
RC radical cystectomy; IQR interquartile range; ECOG-PS Eastern Cooperative Oncology Group-Performance Status, NMIBC non-muscle invasive bladder cancer (T1/isolated Tis), BMI body mass index, PNI prognostic nutritional index, CONUT controlling nutritional status, Hb hemoglobin, CRP C-reactive protein LDH lactate dehydrogenase
† According to the definition for the Martin's definition [21]
¶ Comparison between non-sarcopenia cases and sarcopenia cases female with Mann-Whitney U test or chi-squared test