Table 3.

Univariate and multivariate analysis of prognostic variables in 89 cases undergoing radical cystectomy

Variables	Disease-specific survival						Overall survival
	Univariate			Multivariate			Univariate			Multivariate
	HR	95% CI	P value	HR	95% CI	P value	HR	95% CI	P value	HR	95% CI	P value
Age at RC
≤ 70	1						1
> 70	1.9	0.8–4.2	0.12				1.7	0.8–3.3	0.15
Sex
Male	1						1
Female	1.4	0.5–3.8	0.52				1.3	0.5–3.0	0.57
Clinical T
NMIBC	1			1			1			1
T2	3.1	0.2–39.7	0.38	0.8	0.09–7.0	0.84	1.3	0.2–8.2	0.8	1.3	0.2–11.5	0.78
T3	3.5	0.2–54.0	0.36	0.7	0.08–6.7	0.72	1.1	0.2–9.2	0.9	0.97	0.2–4.9	0.98
T4	4.0	1.2–13.7	0.03	4.1	0.5–35.4	0.20	3.1	1.1–8.8	0.04	6.7	0.8–56.9	0.08
Clinical N
N0	1			1			1			1
N+	11.3	2.8–45.7	0.0006	3.1	1.2–7.8	0.02	3.9	1.2–12.5	0.02	1.9	0.8–4.5	0.15
Variant histology
Negative	1						1
Positive	0.9	0.3–2.2	0.76				0.9	0.4–1.9	0.73
Neoadjuvant chemotherapy
No	1						1
Yes	0.7	0.3–1.5	0.35				0.7	0.3–1.5	0.35
Adjuvant chemotherapy
No	1						1
Yes	1.8	0.6–5.3	0.28				0.7	0.4–1.4	0.72
Sarcopenia status †
No	1			1			1			1
Yes	2.7	1.1–7.2	0.048	1.9	0.8–4.5	0.14	2.3	1.1–5.3	0.046	2.2	1.1–4.6	0.03
Psoas major muscle loss
> −10%	1			1			1			1
≤ −10%	2.2	0.99–4.8	0.052	2.0	0.9–4.7	0.11	2.2	1.2–4.4	0.02	2.4	1.2–4.9	0.02

HR hazard ratio, CI confidence interval, RC radical cystectomy, NMIBC non-muscle invasive bladder cancer (T1/isolated Tis)

^† According to the definition for the Martin's definition [21]