Figure 2. Elevated anxiety in male but not female mice after conjoint FSI and CIN depletion.
A. Male mice with conjoint FSI and CIN depletion in the dorsal striatum exhibited elevated anxiety in the elevated plus maze. Open arm occupancy: t[19] = 2.26, p = 0.036; closed arm occupancy: t[19] = 1.85, p = 0.081; n = 10 C46, 11 A46. See also Supplementary Figure S2. B. Female mice with conjoint FSI and CIN depletion, in contrast, showed no significant change in anxiety. Open arm occupancy: t[16] = 0.75, p = 0.46; closed arm occupancy: t[16] = 1.51, p = 0.15; n = 9, 9.