Figure 3.

Astragaloside IV decreased LPS-stimulated activation of ERK in renal tissue during endotoxinemia. The concentration of p-ERK in renal tissue was detected by ELISA. Levels of p-ERK increased in LPS-treated animals. AS-IV decreased the concentration of p-ERK as the dose increased in LPS-subjected animals. High-dose AS-IV markedly decreased the concentration of p-ERK in LPS-subjected animals compared to the LPS group (mean ±SEM, n=8/group). * Indicates that p<0.05 when compared to the LPS group. LPS – lipopolysaccharide; LA – low-dose AS-IV; MA – medial-dose AS-IV; HA – high-dose AS-IV; ERK – extracellular signal-regulated kinases.