Table 1.
Characteristics (age, gender, prescriptions and co-morbidities before index date) of patients in the study population (Swedish patients, followed 2001–2012), stratified by statin usage and low density lipoprotein (LDL)-cholesterol measurement.
| Variable | No statin, No LDL value | No statin, With LDL value | High statin, No LDL value | High Statin, With LDL value | Total |
|---|---|---|---|---|---|
| N | 17,122 | 3923 | 5563 | 4496 | 31,104 |
| Age (y) at index date (mean) | 75.26 | 70.338 | 65.528 | 66.167 | 71.584 |
| Female (%) | 7855 (46) | 1578 (40) | 1674 (30) | 1440 (32) | 12,547 (40) |
| Male (%) | 9267 (54) | 2345 (60) | 3889 (70) | 3056 (68) | 18,557 (60) |
| HbA1C in % | 6.1868 | 5.8944 | 5.8477 | 5.6775 | 5.8987 |
| BMI, kg/m2 | 26.386 | 27.647 | 27.823 | 28.684 | 27.838 |
| LDL during study in mg/dL | |||||
| N | 0 | 3923 | 0 | 4496 | 8419 |
| Mean (SD) | 0 | 135.56 (37.20) | 0 | 117.98 (36.88) | 126.17 (38.05) |
| Median | 0 | 133.17 | 0 | 114.18 | 123.52 |
| Range | 0, 0 | 28.4, 294.6 | 0, 0 | 16.1, 281.8 | 16.1, 294.6 |
| Interquartile range | 110.0, 158.3 | 91.9, 140.8 | 99.2, 150.5 | ||
| Missing values | 17,122 | 0 | 5563 | 0 | 22,685 |
| HDL during study in mg/dL | |||||
| N | 118 | 3887 | 49 | 4483 | 8537 |
| Mean (SD) | 79.46 (66.35) | 51.82 (16.80) | 44.14 (26.29) | 50.12 (13.67) | 51.27 (17.40) |
| Median | 46.32 | 48.99 | 38.60 | 47.86 | 48.25 |
| Range | 21.2, 227.7 | 15.4, 227.7 | 19.3, 204.6 | 15.8, 135.1 | 15.4, 227.7 |
| Interquartile range | 34.9, 84.9 | 40.5, 59.4 | 34.6, 45.0 | 40.5, 57.9 | 40.5, 57.9 |
| Missing values | 17,004 | 36 | 5514 | 13 | 22,567 |
| Any diabetes before index date, Yes/No | |||||
| No | 14,994 (88) | 3461 (88) | 4855 (87) | 3968 (88) | 27,278 (88) |
| Yes | 2128 (12) | 462 (12) | 708 (13) | 528 (12) | 3826 (12) |
| % patients with diagnosis of any cardiovascular diseases (I0-I99) | |||||
| No | 4187 (24) | 955 (24) | 1334 (24) | 1066 (24) | 7542 (24) |
| Yes | 12,935 (76) | 2968 (76) | 4229 (76) | 3430 (76) | 23,562 (76) |
| Any angina before index date, Yes/No | |||||
| No | 14,931 (87) | 3405 (87) | 4833 (87) | 3914 (87) | 27,083 (87) |
| Yes | 2191 (13) | 518 (13) | 730 (13) | 582 (13) | 4021 (13) |
| Any depression before index date, Yes/No | |||||
| No | 16,356 (96) | 3754 (96) | 5329 (96) | 4325 (96) | 29,764 (96) |
| Yes | 766 (4.5) | 169 (4.3) | 234 (4.2) | 171 (3.8) | 1340 (4.3) |
| Any COPD before index date, Yes/No | |||||
| No | 16,525 (97) | 3766 (96) | 5369 (97) | 4315 (96) | 29,975 (96) |
| Yes | 597 (3.5) | 157 (4) | 194 (3.5) | 181 (4) | 1129 (3.6) |
| Any asthma before index date, Yes/No | |||||
| No | 16,601 (97) | 3790 (97) | 5384 (97) | 4338 (96) | 30,113 (97) |
| Yes | 521 (3) | 133 (3.4) | 179 (3.2) | 158 (3.5) | 991 (3.2) |
| Any cancer before index date, Yes/No | |||||
| No | 16,080 (94) | 3698 (94) | 5240 (94) | 4214 (94) | 29,232 (94) |
| Yes | 1042 (6.1) | 225 (5.7) | 323 (5.8) | 282 (6.3) | 1872 (6) |
| Any rheumatic disease before index date, Yes/No | |||||
| No | 16,790 (98) | 3852 (98) | 5474 (98) | 4406 (98) | 30,522 (98) |
| Yes | 332 (1.9) | 71 (1.8) | 89 (1.6) | 90 (2) | 582 (1.9) |
| Any heart failure before index date, Yes/No | |||||
| No | 17,121 (100) | 3923 (100) | 5563 (100) | 4496 (100) | 31,103 (100) |
| Yes | 1 (0.01) | 0 (0) | 0 (0) | 0 (0) | 1 (0) |
| Any hypertension before index date, Yes/No | |||||
| No | 12,433 (73) | 2859 (73) | 4013 (72) | 3268 (73) | 22,573 (73) |
| Yes | 4689 (27) | 1064 (27) | 1550 (28) | 1228 (27) | 8531 (27) |