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Systemic administration of NaIO3 results in activation of necroptosis in the RPE. (A) Immunohistochemistry shows the translocation of HMGB1 protein out of the nucleus (red arrows) 3 days after systemic administration of NaIO3. By contrast, control eyes did not show any translocation of the HMGB1 (white arrows). (B) NaIO3 treatment also resulted in increased expression of RIPK3. **P < 0.01. ONL, outer nuclear layer; IS, inner segment; OS, outer segment. Scale bars: 20 μm.
