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. 2017 Mar;58(3):1768–1778. doi: 10.1167/iovs.16-20745

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Copyright 2017 The Authors

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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ON- and OFF-responses of RGCs in Lrit3^nob6/nob6 retinas. Representative RGC activity recording from an Lrit3^+/+ retina (A) and an Lrit3^nob6/nob6 retina (B). The gray box corresponds to the light stimulus. Horizontal scale bar: 500 ms; vertical scale bar: 50 μV. Representative raster plot (up) and peristimulus time histogram (bottom) from an Lrit3^+/+ retina (C) and an Lrit3^nob6/nob6 retina (D). The gray box corresponds to the light stimulus. Horizontal scale bar: 1 second; vertical scale bar: 50 events/bin. Maximum firing rate of ON- (E) and OFF-responses (F) in Lrit3^nob6/nob6 retinas compared to Lrit3^+/+ retinas relative to the spontaneous activity. Bars represent median values. Asterisks represent results that are significantly different (P < 0.05). (G) Time for which the maximum firing rate is reached after the light stimulus onset for ON-responses in Lrit3^+/+ retinas and the light stimulus offset for OFF-responses in Lrit3^nob6/nob6 retinas compared to Lrit3^+/+ retinas. Bars represent median values. Asterisks represent results that are significantly different (P < 0.05).