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In vivo and ex vivo total brain volumes for wild-type, rTg4510 and rTg4510 (+DOX) animals. In vivo vs. ex vivo comparisons: ****p ≤ 0.0001. In vivo TBV comparisons: ++p ≤ 0.01; ++++p ≤ 0.0001. Ex vivo TBV comparisons: −−p ≤ 0.01; −−−−p ≤ 0.0001. Whiskers represent the maximum and minimum values.
