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. 2017 Mar 31;11:20. doi: 10.3389/fninf.2017.00020

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Copyright © 2017 Holmes, Powell, Ma, Ismail, Harrison, Wells, Colgan, O'Callaghan, Johnson, Murray, Ahmed, Heggenes, Fisher, Cardoso, Modat, O'Neill, Collins, Fisher, Ourselin and Lythgoe.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TBM results for the morphological comparison between rTg4510 mice and doxycyline-treated rTg4510 mice. Results from (A) in vivo and (B) ex vivo structural analysis, showing TBM statistical results overlaid on representative axial and coronal slices of the final group average image after 20 iterations of NRR. Red: regions where the rTg4510 brains are relatively locally smaller than the treated rTg4510 brains; blue: rTg4510 brains are locally larger. Based upon FDR-corrected t-statistics (q = 0.05).