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. 2017 Mar 31;11:20. doi: 10.3389/fninf.2017.00020

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Copyright © 2017 Holmes, Powell, Ma, Ismail, Harrison, Wells, Colgan, O'Callaghan, Johnson, Murray, Ahmed, Heggenes, Fisher, Cardoso, Modat, O'Neill, Collins, Fisher, Ourselin and Lythgoe.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immunohistochemistry to estimate cortical NeuN and PG-5 positive cell density. Representative coronal slice illustrating the distribution of (A) NeuN and (C) PG-5 positive neurons in the cortex of an untreated rTg4510 mouse. Quantitative estimates of (B) NeuN and (D) PG-5 positive cell density in the cortex for each of the 7 wild-type, 10 untreated rTg4510 and 6 treated rTg4510 mice at 7.5 months of age. Whiskers represent the maximum and minimum values. ^*p ≤ 0.05; ^**p ≤ 0.01; ^***p ≤ 0.001; ^****p ≤ 0.0001.