Table II.
Glucose metabolism and the tricarboxylic acid cycle.
| Metabolite | Reference | Model pathology | Variation | Sample | Author, year (Refs.) |
|---|---|---|---|---|---|
| Citrate | HBV | HEV | - | Urine | Munshi, 2011 (8) |
| Control (HCV) | Cirrhosis (HCV) | + | Serum | Embade, 2016 (15) | |
| Healthy or cirrhosis | HCC | - | Urine | Shariff, 2011 (22) | |
| Functional liver | Non-functional liver | + | Blood | Serkova, 2007 (19) | |
| transplantation | transplantation | (extraction) | |||
| Cirrhosis | Mild or moderate fibrosis gravity | + | Serum | Amathieu, 2011 (13) | |
| Fumarate | Control | HEV+HBV | - | Plasma | Munshi, 2011 (8) |
| Succinate | Control | HBV | - | Urine | Munshi, 2011 (8) |
| Control | Cirrhosis (HBV or EtOH) | + | Serum | Qi, 2012 (8) | |
| Control | Decompensated cirrhosis | + | Serum | Qi, 2012 (10) | |
| Glucose | Adjacent tissues | HCC | - | Liver tissue | Yang, 2007 (6) |
| Controls (HCV) | Cirrhosis (HCV) | + | Serum | Embade, 2016 (15) | |
| Cirrhosis | Fibrosis | - | Liver tissue | Martínez-Granados, 2011 (14) | |
| Low-grade HCC | High-grade HCC | - | Liver tissue | Yang, 2007 (6) | |
| Control | Cirrhosis (HBV or EtOH) | + | Serum | Qi, 2012 (8) | |
| Cirrhosis with low chronic liver failure severity | Cirrhosis with high chronic liver failure severity | + | Serum | Amathieu, 2011 (13) | |
| Cirrhosis-MHE | Cirrhosis+MHE | + | Serum | Jimenez, 2010 (21) | |
| Glycogen | Adjacent tissue | HCC | - | Liver tissue | Yang, 2007 (6) |
| Low grade HCC | High grade HCC | - | Liver tissue | Yang, 2007 (6) | |
| Mild Fibrosis (HCV) | Moderate fibrosis or cirrhosis (HCV) | - | Liver tissue | Cobbold, 2010 (12) | |
| Lactate | Control | Cirrhosis (HBV or EtOH) | - | Serum | Qi, 2012 (8) |
| HEV | HBV | - | Plasma | Munshi, 2011 (8) | |
| Functional liver | Non-functional liver | + | Blood | Serkova, 2007 (19) | |
| transplantation | transplantation | (extraction) | |||
| Low-grade HCC | High-grade HCC | + | Liver tissue | Yang, 2007 (6) | |
| Cirrhosis-MHE | Cirrhosis+MHE | + | Serum | Jimenez, 2010 (21) | |
| Cirrhosis with low chronic liver failure severity | Cirrhosis with high chronic liver failure severity | + | Serum | Amathieu, 2011 (13) | |
| Pyruvate | Control | Cirrhosis (HBV or EtOH) | + | Serum | Qi, 2012 (8) |
| Control | Decompensated cirrhosis | + | Plasma | McPhail, 2016 (23) | |
| Control | NAFLD | + | Serum | Cheng, 2015 (9) | |
| Compensated cirrhosis | Decompensated cirrhosis | + | Serum | Qi, 2012 (10) | |
| Cirrhosis with low chronic liver failure severity | Cirrhosis with high chronic liver failure severity | + | Serum | Amathieu, 2011 (13) |
HBV, hepatitis B virus; HEV, hepatitis E virus; HCV, hepatitis C virus; HCC, hepatocellular carcinoma; EtOH, ethanol; MHE, minimal hepatic encephalopathy; NAFLD, non-alcoholic fatty liver disease.