Figure 1.

Chart showing the family pedigree of the case patient, showing that she had two elder sisters, one of whom (the eldest) died from pancreatic cancer at 60 years of age, while the other remained healthy at 70 years of age. The patient's parents died from causes unrelated to cancer. To the best of the patient's knowledge, no other family members (7 uncles or aunts, and 3 nephews and their descendants) have experienced cancer. The patient's 40-year-old daughter and 36-year-old son underwent genetic testing for the PALB2 mutation, revealing the daughter is affected, whereas the son is not. The black circle indicates the affected individual, and the arrows indicate tested individuals. MI, myocardial infarction.