Table 2. Comparison of antibody SI and histological features (p-values, 2-tailed exact values from Mann–Whitney U tests).
| EGFR25 (ICD) | EGFR113 (ECD) | Ph-EGFR | EGF | TGFα | |
|---|---|---|---|---|---|
| Mitosis 4+ (n = 41) | 0.430 | 0.317 | 0.057 | 0.545 | 0.307 |
| Brain infiltration present (n = 13) | 0.248 | 0.221 | 0.574 | 0.254 | 1.000 |
| Sheeting present (n = 14) | 0.509 | 0.035 | 0.133 | 0.467 | 0.604 |
| Macronucleoli present (n = 11) | 0.440 | 0.684 | 0.216 | 0.478 | 0.622 |
| Hypercellularity absent (n = 140) | 0.200 | 0.579 | 0.445 | <0.001 | 0.733 |
| Small cell change present (n = 18) | 0.228 | 0.259 | 0.206 | 0.509 | 0.380 |
| Necrosis present (n = 40) | 0.416 | 0.877 | 1.000 | 0.210 | 0.073 |
| Psammoma bodies absent (n = 61) | 0.005 | <0.001 | 0.259 | 0.168 | 0.108 |
| Grade II vs grade I (total: n = 185) | 0.983 | 0.787 | 0.018a | 0.040b | 0.113 |
Notes.
- Values in bold
- statistically significant
- Ph-EGFR
- phosphorylated EGFR
- Brain infiltration
- n = 65 where brain tissue was observed
a
SI significantly higher in Grade II than in Grade I.
b
SI significantly higher in Grade I than in Grade II.
p-values between 1% and 5% should be interpreted with caution due to multiple hypotheses. (The present/absent annotations in the first column indicate the characteristic associated with high SI values for bold values only).