Figure 1.

Illustration of structures of CaM and sequences of the target peptides. (a) Solution structure of Ca²⁺-free CaM (apoCaM) (PDB: 1CFD) and crystal structure of Ca²⁺/CaM (holoCaM) (PDB: 1CLL). CaM is colored as follows, red → nCaM (residue 1–76), gray → central linker (residue 77–82), blue → cCaM (residue 83–148), and the Ca²⁺ ions are colored in green; Ca²⁺ binding sites are labeled from I to IV. (b) Structure of Ca²⁺/CaM-dependent kinase II (CaMKII) peptide from the holoCaM-CaMKII crystal structure (PDB: 1CDM) and the sequence of the peptide. (c) X-ray structure of holoCaM-CaMKII (PDB: 1CDM). CaM and the Ca²⁺ ions are colored as in (a) and the CaMKII peptide is colored in green. (d) Sequence of the neurogranin peptide (Ng_13–49). The two minimum compositions of the Ng_13–49 peptide are marked as “acidic region” and “IQ motif.” To see this figure in color, go online.