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. Author manuscript; available in PMC: 2017 Sep 8.
Published in final edited form as: Nature. 2017 Mar 8;543(7645):447–451. doi: 10.1038/nature21705

Figure 3. HIF-1α and CITED2 bind TAZ1 through both static and dynamic interactions.

Figure 3

{1H}-15N heteronuclear NOE values for 15N-HIF-1α (a) and 15N-CITED2 (b) peptides in complex with TAZ1. The amino acid sequences of the HIF-1α and CITED2 transactivation domains and the positions of the helical motifs formed upon TAZ1 binding are shown above the data. The conserved LP(Q/E)L motif is shown in red. In b, data points to the right of the dashed vertical line are plotted according to the right y-axis. The data shown represent the average (circles) and standard deviation (error bars) of three repeated experiments.