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. Author manuscript; available in PMC: 2017 Mar 31.
Published in final edited form as: Catalysts. 2016 May 27;6(6):81. doi: 10.3390/catal6060081

Figure 2.

Figure 2

Conformational states experienced by HIV-1 PR as it proceeds through its catalytic cycle. Crystal structures of HIV-1 PR in the semi-open (PDB 1HHR), closed (PDB 1HVR) and wide open (PDB 1TW7) conformations. The catalytic Asp25 residues from each protomer are depicted as cyan sticks and the “flaps” are depicted in red. The hinge loop, corresponding to residues 34–42, is shown in blue. The curled/tucked conformation of HIV-1 PR is not depicted, since it has never been crystallographically resolved.