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. Author manuscript; available in PMC: 2017 Mar 31.
Published in final edited form as: Catalysts. 2016 May 27;6(6):81. doi: 10.3390/catal6060081

Figure 4.

Figure 4

Schematic representation of the catalytic mechanism of Pol β. Eo and Ec correspond to the open and closed conformations of the enzyme. Sequential binding of the DNA (DNAn) and dNTP leads to the formation of the binary (step 1) and ternary complexes (step 2), respectively. Subsequent conformational rearrangement of the enzyme (Ec) aligns the active site for catalysis (step 3). The chemical step of catalysis is followed by the release of pyrophosphate (PPi) and the DNA product (DNAn+1) (step 4). Figure adapted from [108,109].