Fig 6. Statistical power of tests of interaction, ${\text{R}}_G^2=0.05\%,{\text{R}}_I^2=0.05\%$.

MR5_I: MR test of interaction with 5 strata within each study; MR5_G&I: MR joint test of the genetic main effect and interaction with 5 strata within each study; MR10_I: MR test of interaction with 10 strata within each study; MR10_G&I: MR joint test of the genetic main effect and interaction with 10 strata within each study; JMA_I: JMA test of interaction; JMA_G&I: JMA joint test of the genetic main effect and interaction; and MEGA_I: mega-analysis test of interaction; and MEGA_G&I: mega-analysis joint test of the genetic main effect and interaction.