Table 2.
Fifteen Strongest Associations of a Serum Metabolomics Study with Outcome Variable Dryness and Irritation Symptoms
| Metabolite | Pathway | Super-pathway | P Value | β |
|---|---|---|---|---|
| 4-Androsten-3beta,17beta-diol disulfate 2 | Sterol/steroid | Lipid | 2.9E-08∗ | −0.16 |
| Androsterone sulfate | Sterol/steroid | Lipid | 0.0000040∗ | −0.11 |
| Epiandrosterone sulfate | Sterol/steroid | Lipid | 0.000016∗ | −0.11 |
| 4-Androsten-3beta,17beta-diol disulfate 1 | Sterol/steroid | Lipid | 0.000064∗ | −0.11 |
| DHEA-S | Sterol/steroid | Lipid | 0.00011∗ | −0.10 |
| 3-(4-Hydroxyphenyl)lactate | Phenylalanine and tyrosine metabolism | Amino acid | 0.0021 | −0.07 |
| Glycerol | Glycerolipid metabolism | Lipid | 0.00394 | 0.07 |
| Erythronate | Amino sugars metabolism | Carbohydrate | 0.025 | 0.05 |
| Heptanoate (7:0) | Medium-chain fatty acid | Lipid | 0.027 | 0.05 |
| Allantoin | Purine metabolism, urate metabolism | Nucleotide | 0.028 | 0.06 |
| 1,7-Dimethylurate | Xanthine metabolism | Xenobiotics | 0.031 | 0.06 |
| Linolenate (α or γ [18:3n3 or 6]) | Essential fatty acid | Lipid | 0.031 | 0.05 |
| 1-Oleoylglycerophosphoethanolamine | Lysolipid | Lipid | 0.036 | 0.05 |
| Caproate (6:0) | Medium-chain fatty acid | Lipid | 0.042 | 0.05 |
| Linoleate (18:2n6) | Essential fatty acid | Lipid | 0.043 | 0.05 |
DHEA-S = dehydroepiandrosterone sulfate.
∗
Metabolome-wide significant association (P < 0.0012).