Table 3.
Fifteen Strongest Associations of a Serum Metabolomics Study with Outcome Variable a Clinical Diagnosis of Dry Eye Disease
| Metabolite | Pathway | Super-pathway | P Value | β |
|---|---|---|---|---|
| Epiandrosterone sulfate | Sterol/steroid | Lipid | 0.00029∗ | −0.22 |
| Androsterone sulfate | Sterol/steroid | Lipid | 0.0011∗ | −0.20 |
| DHEA-S | Sterol/steroid | Lipid | 0.0041 | −0.18 |
| 4-Androsten-3beta,17beta-diol disulfate 1 | Sterol/steroid | Lipid | 0.014 | −0.17 |
| N1-methyladenosine | Purine metabolism, adenine containing | Nucleotide | 0.017 | −0.14 |
| Serine | Glycine, serine, and threonine metabolism | Amino acid | 0.026 | 0.13 |
| 1-Palmitoylglycerophosphocholine | Lysolipid | Lipid | 0.030 | −0.12 |
| 4-Androsten-3beta,17beta-diol disulfate 2 | Sterol/steroid | Lipid | 0.034 | −0.14 |
| 5-Dodecenoate (12:1n7) | Medium-chain fatty acid | Lipid | 0.048 | −0.12 |
| Xanthine | Purine metabolism, (hypo)xanthine/inosine containing | Nucleotide | 0.051 | −0.13 |
| Theophylline | Xanthine metabolism | Xenobiotics | 0.051 | 0.12 |
| Myristoleate (14:1n5) | Long-chain fatty acid | Lipid | 0.054 | −0.12 |
| Indolelactate | Tryptophan metabolism | Amino acid | 0.057 | −0.11 |
| Myristate (14:0) | Long-chain fatty acid | Lipid | 0.059 | −0.12 |
| 1-Stearoylglycerophosphocholine | Lysolipid | Lipid | 0.063 | −0.11 |
DHEA-S = dehydroepiandrosterone sulfate.
∗
Metabolome-wide significant association (P < 0.0012).