Epitope location on the cryo-EM structures of BPL-inactivated CVA16 capsids. (A) A single asymmetric unit of our cryo-EM map of the BPL-treated CVA16 mature virion. Densities for VP1, VP2, and VP3 are rendered in blue, green, and red, respectively. (B) Previously identified linear neutralizing epitopes of CVA16 in the asymmetric unit shown in panel A. (C) A single asymmetric unit of our cryo-EM map of the BPL-treated CVA16 procapsid. (D) Previously identified linear neutralizing epitopes of CVA16 in the asymmetric unit shown in panel C. Epitopes are colored as follows: PEP32, residues 94 to 108 of VP1, pink; PEP37, residues 109 to 123 of VP1, cyan; PEP55, residues 163 to 177 of VP1, magenta; PEP63, residues 187 to 201 of VP1, light green; PEP71, residues 211 to 225 of VP1, yellow; PEP91, residues 271 to 285 of VP1, orange.