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MMP-9 facilitates the replication of VSV by attenuating IFN-α action. HepG2 cells were transfected with pCMV-Tag2B-MMP-9 for 24 h and infected with VSV-GFP (MOI = 0.01) for 24 h. GFP levels were measured by Western blotting (A) and fluorescence microscopy (B), and relative levels of GFP-positive cells are shown in graph (C). Results show means ± standard deviations (n = 3). *, P < 0.05; **, P < 0.01; ns, nonsignificant.
