FIG 9.

A synthetic CD4 mimetic modulates binding of nnAbs and bNAbs and ADCC. (A) Primary CD4 T cells infected with HIV-1 (KB18v isolate) were incubated with mCD4.2-PS1 (10 nM) for 10 min before measurement of Ab binding by flow cytometry. Data from one representative experiment (out of 3) are shown. (C) ADCC was evaluated in the presence or absence of mCD4.2-PS1. Results are means ± standard errors of the means from three independent experiments. Results are means ± standard errors of the means with NK cells from three donors.