Ribbon representation of our computational model of the E1/E2 heterodimer, with E1 in teal and E2 in green and with some of the regions discussed in the text highlighted by using color and labeling. Residues important for CD81 binding are shown in red, HVR1 is in black, HVR2 is in orange, IgVR is in brown, the ApoB/ApoE binding peptides are in yellow, and the putative fusion peptide is in dark blue. All cysteine residues are shown in a line representation.