FIG 2.

(a and b) Structural alignment of our nE1 homology model (yellow) with structures reported under PDB accession numbers 1LN2 (34) (dark blue) (a) and 4UOI (20) (monomers in teal and pink, respectively) (b). The α-helix and two more β-strands that were added to the C-terminal end of nE1 by Rosetta are shown in magenta and green, respectively, and a similarly positioned α-helix in the structure reported under PDB accession number 1LN2 is shown in red. (c) Sequence alignment of the nE1 sequence with the sequence corresponding to the structure reported under PDB accession number 1LN2, color-coded by similarity, with dark blue representing identity and red representing clashes. The thick colored line above the sequence reported under PDB accession number 1LN2 is color-coded by secondary structure, with blue representing turns, white representing loops, red representing helical regions, and yellow representing β-strands.