Table 1.

Effects of ivabradine and its combination with four classical antiepileptic drugs on long-term memory in the passive avoidance task, motor performance in the chimney test and muscular strength in the grip-strength test in mice

Treatment (mg/kg)	Retention time (s)	Muscular strength (N)	Motor coordination impairment (%)
Vehicle	180 (180; 180)	1.087 ± 0.067	0
Ivabradine (10) + Vehicle	180 (180; 180)	1.052 ± 0.071	12.5
Carbamazepine (12.5) + Ivabradine (10)	180 (180; 180)	1.049 ± 0.065	0
Phenobarbital (26.9) + Ivabradine (10)	180 (180; 180)	1.048 ± 0.062	0
Phenytoin (18.0) + Ivabradine (10)	180 (180; 180)	1.062 ± 0.072	0
Valproate (248.2) + Ivabradine (10)	177.5 (155.5; 180)	1.063 ± 0.069	12.5

Results are presented as: median retention times [in seconds (s); with 25th and 75th percentiles in parentheses] from the passive avoidance task; mean muscular strengths [in newtons (N) ± S.E.M.] from the grip-strength test; and percentage (%) of animals with impairment of motor coordination from the chimney test. Each experimental group consisted of 8 mice