Fig. 1.

Effects of EP4 receptor on SAH grade, mortality and neurological score 24 h after SAH. Representative images showed rat brains of sham and SAH groups (a). EP4 modulation did not affect the SAH grade (n = 12) (b). The activation of EP4 by AE1-329 decreased mortality (n = 28) and attenuated neurological deficits (n = 12) 24 h after SAH while the inhibition of EP4 by AE3-208 showed opposite effects (c, d). Data were expressed as mean ± SEM (^###p < 0.001 vs. Sham, * p< 0.05 vs. SAH treated with vehicle, **p < 0.01 vs. SAH treated with vehicle)