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. 2017 Mar 15;9(3):1139–1150.

Figure 6.

Figure 6

Involvement of activation of the Nrf2/HO-1 signaling pathway in the protective effects of LA4 in rats with skeletal muscle I/R injury. A. Protein expression of Nrf2 and HO-1. B, C. Quantification of Nrf2 and HO-1 levels showing LA4 dose dependently activated the Nrf2/HO-1 signaling pathway. D, E. ZnPP administered 1 h before ischemia and HO-1 protein expression determined by Western blotting. F. Skeletal muscle edema. G. Representative images of HE staining from I/R + vehicle group, I/R + 10 μg/kg LA4 + vehicle group, and I/R + 10 μg/kg LA4 + ZnPP group (scale bar = 50 μm). H. Histological damage scores. Results are expressed as mean ± SD. #P < 0.05 compared with sham group; **P < 0.01 compared with I/R group; ##P < 0.01 compared with I/R + vehicle group; &P < 0.05 compared with IR + 10 μg/kg LA4 + vehicle group.