Figure 3.

HS attenuates isoflurane-induced opening of mPTP. Data are shown as the relative percent of the initial OD at an absorbance of 540 nm. Mitochondria from H4-APP cells treated with both the isoflurane condition and the control condition show swelling in response to Ca²⁺, with mitochondria from isoflurane-treated cells showing greater swelling than those from control cells. Mitochondria from cells treated with isoflurane plus HS are more resistant to Ca²⁺-induced swelling and permeability transition than those from cells treated with isoflurane plus saline.