Figure 5.

Silencing of miR-1246 reduces LPS-induced lung permeability. Mice were intratracheally administered with control inhibitor or anti-miR-1246 (2 mg/kg) 24 h before exposure to LPS or PBS. A: Evans blue dye extravasation assay revealed that LPS-induced lung permeability was significantly blocked by depletion of miR-1246. B: Total cells and neutrophils in BAL fluids were counted. C: TNF-α and IL-1β levels in BAL fluids were quantified by ELISA. D: Measurement of total protein levels in BAL fluids. *P < 0.05.